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In Vitro Mammalian Cell Micronucleus Test (MNvit, OECD 487)
The MNvit detects micronuclei in interphase cells, capturing both clastogenic and aneugenic chromosome damage in a single, regulatory-recognised assay.
What's inside
- Principle of the in vitro micronucleus test (MNvit)
- Detection of both aneugens and clastogens
- Micronucleus formation during cell division
- Regulatory context: OECD 487
The in vitro micronucleus test (MNvit) is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei are small nuclei that separate from the main nucleus during cell division, produced by lagging chromosome fragments or whole chromosomes that are not incorporated into the daughter nuclei.
Because micronuclei arise from both whole chromosomes and chromosome fragments, the MNvit detects the chromosome-damaging potential of both aneugens (substances causing an abnormal number of chromosomes) and clastogens (substances that break or disrupt chromosomes).
Who this is for
- Pharmaceutical and biotech genotoxicity teams
- Cosmetic ingredient safety assessors
- Regulatory affairs requiring chromosome-damage data
Recommended citation
GenEvolutioN Scientific Team (2025). In Vitro Mammalian Cell Micronucleus Test (MNvit, OECD 487). GenEvolutioN Technologies.