Mutagenicity testing assesses whether a substance can induce genetic mutations, which can lead to carcinogenic risks. These studies are critical for early-stage screening and regulatory compliance.

• OECD 471 – Ames Test → Detects point mutations in bacteria to identify DNA-reactive substances.

• OECD 471 – Enhanced Ames Test → Optimized for detecting N-nitrosamines and NDSRIs, improving sensitivity in regulatory assessments.

• OECD 476 – HPRT Gene Mutation Test → Evaluates mammalian cell mutations to identify genotoxic risks.

• OECD 490 – Mammalian Lymphoma Assay (MLA) → Detects both point mutations and chromosomal damage.

GenEvolutioN ensures high-throughput and precise mutagenicity assessments, providing data essential for regulatory decision-making.

Cytogenicity testing determines whether a substance induces structural (clastogens) or numerical (aneugens) chromosomal damage, both of which contribute to genotoxicity and carcinogenic potential.

• OECD 487 – Micronucleus Test → Detects chromosomal breakage or loss in mammalian cells, distinguishing between clastogenic and aneugenic activity.

• OECD 473 – Chromosomal Aberration Assay (CAA) → Evaluates structural chromosomal alterations, a key indicator of genetic toxicity.

Skin toxicology studies assess the potential irritation, corrosion, and phototoxicity effects of chemicals, helping to comply with international safety regulations.

• OECD 439 – Skin Irritation Test (RhE Model) → Evaluates skin irritation potential using reconstructed human epidermis.

• OECD 431 – Skin Corrosion Test (RhE Model) → Determines severe skin damage risks.

• OECD 492 – Ocular Irritation Test (RhCE Model) → Assesses eye irritation potential using a reconstructed human cornea model.

• OECD 432 – Phototoxicity Test (3T3 NRU & RhE Models) → Evaluates adverse effects induced by UV light exposure.

GenEvolutioN leverages non-animal in-vitro testing solutions, offering accurate and ethical alternatives for regulatory safety evaluations.

Skin sensitization assessments detect whether substances can trigger allergic responses, a critical concern for pharmaceuticals, cosmetics, and chemicals.

• OECD 442C – DPRA/kDPRA → Analyzes peptide reactivity to predict sensitization potential.

• OECD 442D – KeratinoSens Assay → Detects cellular stress activation in human keratinocytes.

• OECD 442E – Senzagen GARD Assay → Uses gene expression profiling to identify sensitizing chemicals.

With comprehensive in-vitro methodologies, GenEvolutioN ensures reliable and regulatory-compliant skin sensitization screening.