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In Vitro Pig-a Mutation Test on L5178Y Cells
Pharma Cosmetic
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Reconstructed Skin Micronucleus Test (RSMN) on EpiDerm
Using the EpiDerm reconstructed-skin model in the RSMN assay to detect genotoxicity under realistic dermal exposure — supporting non-animal risk assessment under the EU Cosmetics Regulation.
What's inside
- The Reconstructed Skin Micronucleus test (RSMN)
- EpiDerm 3D skin model and realistic exposure
- Genotoxic risk for topical / transdermal products
- Non-animal methods under EU Cosmetics Regulation
The Reconstructed Skin Micronucleus test (RSMN) on the EpiDerm model detects DNA damage under conditions that mimic realistic dermal exposure. This makes it particularly valuable for evaluating the genotoxic risk of topical and transdermal drugs and of cosmetic ingredients applied directly to the skin.
The model provides a physiologically relevant context — accounting for dermal absorption, metabolism and cellular interactions — and supports accurate, non-animal risk assessment in line with regulatory frameworks such as the EU Cosmetics Regulation, which mandates the use of non-animal methods.
Who this is for
- Cosmetic ingredient safety assessors
- Pharma teams (topical / transdermal)
- Regulatory and academic toxicology
Recommended citation
C. Cuceu Petrenci, J. Raposo, T. Lacour, I. Mouche (GenEvolutioN) (2024). Reconstructed Skin Micronucleus Test (RSMN) on EpiDerm. GenEvolutioN Technologies.
